Pancreatic Blood Test, Profile, 2 in 1 Kit – £65

Pancreatic Issues need attention: A story of the end.

My dad. Age 62. He played sports all his life, did not drink or smoke, and worked physically at a construction site. Lived in the city region. He fasted once a year for 10-15 days from age 25. Both his parents passed away from cancer (lung and stomach). Therefore, he led a healthy lifestyle and ate right. The ailments began with weight loss, followed by greenish and greasy stool changes.

Early Life and Health Background

The intestinal upset lasted a week, after which he went to a gastroenterologist for a test. She prescribed drugs for pancreatitis. They did not help; blood appeared in the stool. Two weeks later, she sent him for an ultrasound, and then a cyst was discovered. They analysed tumour markers – slightly elevated levels. The next step was an MRI with contrast – a 20 mm cystic formation in the head of the pancreas and hemangiomas in the liver (this was July). We went to a district oncologist for a consultation; he could only offer painkillers and a referral.

People often ask about money- I only managed to get chemotherapy for free (I’ll tell you more about it later).

After two weeks of going to the Test Doctor and not understanding what to do or who to contact, Dad started fasting for ten days. He already began to feel a lump in his pancreas by palpation. On August 24, 2018, we saw surgeon Egorov at the Hospital for a consultation. We got through to him at the reception, and he immediately invited us to come for a consultation.

Early Life and Health Background

Egorov is one of the leading surgeons specialising in pancreatic surgeries, including oncology. He looked at the MRI results, but since they were done in an unknown centre and a month had passed, he sent me to do an MRI with contrast at Medscan on a modern device on the same day. Based on the previous study, it was not clear to him whether there were hemangiomas in the liver or metastases. He explained that if these were hemangiomas, surgery was possible; if metastases, only chemotherapy and surgery were possible if the tumour growth stopped.

Regarding fasting, he answered unequivocally – since there are no blood vessels in the pancreatic tissue, fasting only exhausts the body and does not help the matter. Chemotherapy or surgery requires strength. If fasting helped with this Pancreatic Blood Test diagnosis, he would prescribe fasting to everyone. At this point, Dad stopped fasting.

We received the MRI results on 08/27/2018. There was no miracle; it turned out that these were metastases. The cyst in the head of the pancreas had grown to 4 cm by that time (that is, 2 cm in a month). Egorov sent us to chemotherapy. The clinic is private, but they accept people for chemotherapy and hospitalisation under compulsory medical insurance.

Chemotherapy Treatment

To decide which chemotherapy to do, they necessarily do a biopsy (collection of material) and submit it for histology. Pancreatic biopsy is done in only a few clinics and is not fast. You need to get a referral from an oncologist to a specialised hospital, visit the hospital and be hospitalised for 3 days. Since it was summer, many doctors were on vacation. We went another way and agreed to do it at MEDSI in Botkin for a fee. An ultrasound doctor does it, first looks to see if he can get to the cyst and if it is large enough. Then, in the operating room, under ultrasound guidance, he shoots a needle from a gun, which pulls out the biomaterial. Dad had three punctures.

Histology and Immunohistochemistry

The material is placed on glass and paraffin blocks and sent to the lab.  The lab does not communicate with individuals; all requests go through a doctor. Histological examination costs about 11 thousand; it takes 14 working days, and there is no way to speed it up. After 2 weeks, we received the answer – insufficient material; an immunohistochemical examination is required. The chemotherapist shrugs – do it. They gave the tests for another 2 weeks for 16 thousand.

Preparation for Chemotherapy

At this time, a German venous port was installed in MEDSI to undergo chemotherapy. They put you in the hospital for 1 day; the procedure is free according to the policy. After installing the port, you cannot load the shoulder area and arms or lift weights.

Two weeks later, the histochemistry test returned – again, an unclear picture of the presence of atypical cells (cancer). The chemotherapist suggested doing chemotherapy, as for everyone with pancreatic oncology – gemcitabine with ambroxan (full composition: dexamethasone, ondansetron, nab-paclitaxel, saline and gemcitabine ). We agree. And only a month after visiting Egorov – they started chemotherapy. The medical staff perform the procedure in the procedure room, which takes an hour and a half (4 different IVs). Before each chemotherapy session, the patient submits a package of documents and tests according to the list, converses with the chemotherapist, and receives a sheet of appointments. With this sheet, the patient heads to the queue in the procedure room. Dad had to endure the 1.5-hour drive after chemotherapy.

Gene Mutation and Missed Opportunity

When we started travelling, there were few lines, but gradually, the number of people increased. Another remark: The chemotherapist forgot to tell us to analyse the MSI gene mutation. If it is detected, we can do immunostimulating chemotherapy. To avoid wasting time, submit the material for all possible tests simultaneously (histology, immunohistochemistry, and gene mutations).

I took the MSI test at the National Medical Research Center of Oncology, which takes 14 days. By the way, I received this test when Dad had a week to live. The results showed no predisposition to MSI. As the chemotherapist explained over the phone, this means that we could not do immunostimulating chemotherapy.

Chemotherapy is given in courses—once a week for four weeks, followed by a two-week break. During this time, we had an appointment with an oncologist.

We received a referral for a free appointment at the clinic. A few days later, we went, but we encountered a terrible stream of people. This is not a private clinic.

Follow-up appointments and MRI Results

People from other cities come to the Pancreatic appointment with suitcases straight from the train. Since we did not have an appointment with anyone specifically for the initial appointment, we were sent to chemotherapist Toropov. He listened to us and said that the chances were very small. He approved the combination of drugs proposed at MEDSI and said that at least two courses were needed to understand whether there was an effect. After the second course, he advised doing a control MRI and, if possible, coming to them for surgery. He is a radiosurgeon working at their institute (I did not remember his last name), taking on even complex cases. The main indicator is that the superior mesenteric vein is not affected. If it is affected, then no operation is possible.

Dad also went through a second course of chemotherapy. The second course was much harder than the first. There is also a withdrawal syndrome – a couple of days after chemotherapy, it becomes really bad. The worst thing is not only physical discomfort (there was a temperature of 40 and aching bones) but depression. Chemotherapy dries out a lot; blood vessels become brittle.

Appetite disappears. As we found out, in such cases, you can give half a tablet of dexamethasone (part of chemotherapy), which gets a little better.

Follow-Up CT Scan

After the second course of chemotherapy, on November 21, 2018, as prescribed by a chemotherapist from MEDSI, we went for a paid CT scan with contras. CT is done only 2 weeks after the end of chemotherapy; keep this in mind. By then, I was already feeling very bad, quickly tired, and lacking coordination. CT showed that the cyst had increased from 4 cm to 7 cm in diameter, the vessels were affected, and the number of metastases had increased – this was after 3 months of chemotherapy. Hopes for surgery were dashed.

Transition to Aggressive Chemotherapy

The chemotherapist from MEDSI recommended changing the chemotherapy drug to a more aggressive one (oxaliplatin + fluorouracil). But Dad refused, saying that he could not stand chemotherapy anymore. The chemotherapist’s prognosis was extremely honest – no more than 2 months to live.

Then, Dad began to live as long as he had left. His strength was waning; his night sleep was getting worse. This is the hardest period for loved ones when nothing can be done for the patient. My only advice is to be there and hug your loved one more.

Rapid Decline

Two weeks after the CT scan, the volume of fluid found in the abdominal cavity increased, painfully pressing on the organs and interfering with breathing. The stomach swelled, became hard and hurt. They took him by ambulance to a district hospital. When doctors learn the Blood diagnosis, they do not stand on ceremony with a cancer patient. Dad underwent a laparoscopy, pumped out the fluid (there were 3.5 litres), and examined the abdominal cavity. The result of the operation was written – multiple metastases. A week later, they returned home.

Since then, the Pancreatic condition has been consistently bad. Complete loss of appetite, intake of only liquid food – broth and compote. A week after the operation, the belly began to grow again. The surgeon said that a second operation was no longer advisable and advised using painkillers. It is no secret that they have a narcotic effect. The oncologist at the district Blood Clinic gave a prescription for tramadol. We never gave it to him. We used analgin and diphenhydramine, which almost did not help. The body aches were terrible; Dad was constantly tossing and turning and could not lie in one position. Food made him vomit something black. He stopped eating and stopped getting up on his own. The only relief was a bath; it was a little easier in the water.

Passing

He asked to go to the hospital himself so that they would at least do something. The Pancreatic Doctors put in IVs; nothing else was possible. He spent one day in the hospital and did not sleep at all at night. He was constantly freezing, tossing and turning. In the morning, they gave him a painkiller and antiemetic injection; he felt a little better, went limp and passed away on December 26, 2018. This terrible period lasted about 3 weeks, but the last week was the hardest. There was no severe pain, which he was so afraid of. And until the last, he was in his right mind and even joked. He lived 5 months from the moment of diagnosis.