Aciclovir cream

Aciclovir cream, an anti-viral medicine used to treat cold sores is available from Medicinesbymailbox Pharmacy.

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Aciclovir cream

Aciclovir cream

Prescription fees

Medicinesbymailbox supplies medicine on prescription and charges a small prescription fee based on the order value of each prescription.Prescriptions are issued by our doctors online and sent electronically to our pharmacy.If you have your own private paper prescription please post to our pharmacy (details).

Order value Prescription fee
Any Order Value £0.00

Aciclovir product information

Aciclovir cream contains the active ingredient aciclovir, which is a type of antiviral medicine used to treat cold sore. Cold sore is caused by a virus called Herpes Simplex Virus (HPV). Aciclovir can kill or stop the growth of this organism.

Aciclovir 5% cream is available under different brand names, e.g. Zovirax, Boots Antiviral Cold Sore Cream and Virasorb Cold Sore Cream. They are all medically identical with the same active ingredients. 

How to use

Apply a thin film of cream to the affected area five times daily, preferably at the tingling stage before blisters appear. It is recommended to space out the application evenly, ideally every 4 hours. Treatment should be continued for at least 4 days, and can be used for 5 more days if it has not healed after day 4. 

You should wash your hands before and after applying the cream, to prevent spreading the infection. 

Medicinesbymailbox Pharmacy supplies 2 gram and 10 gram tubes. The 2 gram tube is for a single treatment and the 10 gram tube is sufficient for repeated treatments. 

Side effects of Aciclovir cream

Like all medications, aciclovir cream can cause some side effects, although not everyone gets them.

The most common side effects are mild and include burning, redness, itching, drying and flaking skin.

However, you should stop using the cream and consult a doctor immediately if you experience severe allergic reaction such as shortness of breath, swelling of the lips, face or eyelids or a rash.


Although only very small amounts of aciclovir are likely to pass into the body, you should discuss with a doctor or pharmacist before use if you are pregnant or breast feeding.

Patient information leaflet

The 'Patient Information Leaflets' supplied with medication must be read before using the cream.